We are a research group in the UCSF Department of Medicine Lung Biology Center. We are also affiliated with the Department of Bioengineering and Therapeutic Sciences, the Cardiovascular Research Institute, and the Center for Genes, Environments, and Health. Our work aims to contribute to human health by increasing understanding of the genetic and environmental underpinnings of common disease.
We develop statistical and computational tools to discover the genetic basis of complex phenotypes. We are especially interested in human disease, variation in drug/treatment response, and disease outcomes. Current projects primarily focus on incorporating environmental context into medical genetics. These include developing novel techniques to partition the proportion of phenotype driven by genetic and environmental factors in world-wide populations (Nature versus Nurture), and improving our power to identify disease causing mutations by leveraging gene-expression, meta-genomic, and clinical data such as smoking status, BMI, and age.